2 Sep 2021 News The origin of a common compound about 56843-79-9

Statistics shows that 56843-79-9 is playing an increasingly important role. we look forward to future research findings about 4-Chloro-2-methylthieno[2,3-d]pyrimidine.

Related Products of 56843-79-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.56843-79-9, name is 4-Chloro-2-methylthieno[2,3-d]pyrimidine, molecular formula is C7H5ClN2S, molecular weight is 184.65, as common compound, the synthetic route is as follows.

Example 31 : 6,6-dimethyl-3-[(2-methylthieno[2,3-d]pyrimidin-4-yl)amino]-N-[trans-2- phenylcyclopropyl]-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide; A mixture of compound 4b (83 mg, 0.267 mmol) and compound 31c (4-chloro-2-methylthieno[2,3- d]pyrimidine, prepared following same method compound 32c was prepared, 115 mg, 2 eq,) was added an aqueous solution of acetic acid (50% v/v, 1 ml). The resulted mixture was heated and stirred at 1000C for 1 hour. Preparative HPLC purification give the title compound as a white solid (34 mg, 27% yield). 1H EPO NMR (CD3OD) delta: 1.03-1.13 (m, 2 H), 1.69 (s, 3 H), 1.70 (s, 3 H), 1.90-1.99 (m, 1 H), 2.66 (s, 3 H), 2.67-2.75 (m, 1 H), 4.46 (s, 2 H), 6.98-7.19 (m, 5 H), 7.55-7.61 (m, 1 H) 7.63-7.69 (m, 1 H), 8.20 (d, J=6.06 Hz,1 H). LCMS (APCI, M+H+): 460.1. Anal. (C24H25N7OS-LSITFA-O-I SH2O): C, H, N. HPLC-UV Detection:95% purity.

Statistics shows that 56843-79-9 is playing an increasingly important role. we look forward to future research findings about 4-Chloro-2-methylthieno[2,3-d]pyrimidine.

Reference:
Patent; PFIZER INC.; WO2006/72831; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia