Synthetic Route of 6693-08-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6693-08-9, name is 2,4,6-Trichloro-5-fluoropyrimidine. A new synthetic method of this compound is introduced below.
Part B: (3S)-1-(2-Chloro-5-fluoro-6-hydrazino-4-pyrimidinyl)-4,4-dimethyl-3-pyrrolidinol. To a solution of 2,4,6-trichloro-5-fluoropyrimidine (0.3362 g, 1.669 mmol) in DCM (6 ml.) was added (3S)-4,4-dimethyl-3-pyrrolidinol hydrochloride (0.2530 g, 1.691 mmol) and N,N-diisopropylethylamine (0.640 ml_, 3.674 mmol). The solution was stirred for 2 h, and was then concentrated in vacuo. To a solution of the residue in DMSO (4 ml.) was added hydrazine hydrate (0.6 ml_), and the solution was stirred overnight. The solution was then purified directly by Gilson RPLC to give first (3S)-1-(2-chloro-5-fluoro-6- hydrazino-4-pyrimidinyl)-4,4-dimethyl-3-pyrrolidinol (0.1464 g, 32% yield) as an orange solid, LCMS: (M+H)+: 276.0, followed by 4-chloro-5-fluoro-6-[(4S)-4-hydroxy-3,3- dimethyl-1-pyrrolidinyl]-2(1 /-/)-pyrimidinone hydrazone (0.2149 g, 47% yield) as a light pink solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,6693-08-9, 2,4,6-Trichloro-5-fluoropyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2009/61879; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia