Reference of 5018-38-2, Adding some certain compound to certain chemical reactions, such as: 5018-38-2, name is 4,6-Dichloro-5-methoxypyrimidine,molecular formula is C5H4Cl2N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5018-38-2.
To a solution of 4,6-dichloro-5-methoxypyrimidine (20.00 g, 1 12 mmol) in DCE (250 mL) at 0 C was added aluminum trichloride (22.35 g, 168 mmol) in two portions. The reaction mixture was stirred at 0 C for 10 min, then at 50 C for 4 hr. The mixture was cooled to 0 C and aqueous HCI (1 M, 120 mL) followed by MeOH (50 mL) were added slowly while stirring vigorously. The mixture was poured into water and extracted with Et20 (3x). The combined organic layers were washed with brine, dried over magnesium sulfate, filtered and concentrated. The residue was dried in vacuum to afford INT 15 as a beige solid. UPLC-MS: MS (ESI): [M-H]” 163.0, rt = 0.44 min. 1 H NMR (DMSO-d6): delta (ppm) 1 1 .69 (s, br, 1 H), 8.38 (s, 1 H).
According to the analysis of related databases, 5018-38-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NOVARTIS AG; BRIARD, Emmanuelle; AUBERSON, Yves; CENNI, Bruno; PULZ, Robert Alexander; ANGST, Daniela; (62 pag.)WO2016/79669; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia