With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.24391-41-1, name is 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, molecular formula is C7H3ClN4, molecular weight is 178.58, as common compound, the synthetic route is as follows.name: 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
A reaction mixture of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile (24.61 mg; 0.14 mmol; 1.02 eq.), cis-4-[1 -(2-azetidin-1 -yl-ethyl)-4-(4-fluoro-3-trifluoromethyl-phenyl)-1 H- imidazol-2-yl]-3-fluoro-piperidine (56.00 mg; 0.14 mmol; 1 .00 eq.), and ethyldiisopropylamine (22.70 mg; 0.18 mmol; 1 .30 eq.) in ACN (1 ml) was stirred at 50C for 36 hr. After cooling to rt, the precipate was collected by filtration to yield the title compound as a yellow solid. LC-MS (M+H = 557, obsd. = 557).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,24391-41-1, 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, and friends who are interested can also refer to it.
Reference:
Patent; MERCK PATENT GMBH; LAN, Ruoxi; CHEN, Xiaoling; XIAO, Yufang; HUCK, Bayard R.; GOUTOPOULOS, Andreas; WO2014/143612; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia