In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 49845-33-2, name is 2,4-Dichloro-5-nitropyrimidine, the common compound, a new synthetic route is introduced below. SDS of cas: 49845-33-2
[00510] To a solution of 2,4-dichloro-5-nitropyrimidine (582 mg, 3 mmol) in THF (5 mL) wasadded DIEA (775 mg, 6 mmol) and tert-butyl3-aminophenylcarbamate (625 mg, 3 mmol, in 2mL THF) at -78 °C underN2 atmosphere. After stirring at -78 °C for 30 min, the reaction waswarmed up tor. t. and stirred overnight. The reaction was quenched with water (10 mL) andextracted with IPA/DCM (15:85) (5 mL X 3). The combined organic layer was washed withbrine, and dried over Na2S04. The solvents were removed under vacuum and the residue waspurified by flash chromatography (silica gel, 0 to 5percent ethyl acetate in PE/DCM (Ill) with 0.5percentTEA) to provide tert-butyl 3-(2-chloro-5-nitropyrimidin-4-ylamino )phenylcarbamate (1)(1.087g, 99percent) as an orange solid. LC-MS (ESI) m/z (M/M+2) 366.2/368.2.
The synthetic route of 49845-33-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PHARMACYCLICS, INC.; CHEN, Wei; YAN, Shunqi; LOURY, David, J.; FRYE, Leah, Lynn; GREENWOOD, Jeremy, Robert; SHELLEY, Mee, Yoo; WANG, Longcheng; WO2014/130693; (2014); A1;,
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