Electric Literature of 332133-92-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 332133-92-3, name is 4-(Tributylstannyl)pyrimidine. A new synthetic method of this compound is introduced below.
A mixture of 3~(2-amino-5~(bis(4-mefhoxybenzyl)amino)-8~bromo~ il,2,4]triazolo[l,5-c]pyrimidin-7-yl)benzonitrile (350 mg, 0.61 mmol), 4- (tributylstannyi)pyrimidine (210 pL, 0.67 mmol), ietrakis(triphenylphosphine)pailadium(0) (70 mg, 0.060 mmol), copper(l) iodide (23 mg, 0.12 mmol) and cesium fluoride (180 mg, 1.2 mmol) in dioxane (4.7 mL) was heated and stirred at 140 C for 30 min in a microwave reactor. The reaction mixture was then cooled to r.t, filtered through a Celite plug (washed with DCM), and concentrated. The resulting material was purified by silica gel column chromatography eluting with 0-20% MeOH/DCM to give the desired product. LC-MS calculated for C32H28N9O2 (M+H)+: m/z = 570.2; found 570 3.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,332133-92-3, its application will become more common.
Reference:
Patent; INCYTE CORPORATION; WANG, Xiaozhao; GAN, Pei; HAN, Heeoon; HUANG, Taisheng; MCCAMMANT, Matthew S.; QI, Chao; QIAN, Ding-Quan; WU, Liangxing; YAO, Wenqing; YU, Zhiyong; ZHANG, Fenglei; (284 pag.)WO2019/168847; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia