Adding a certain compound to certain chemical reactions, such as: 956034-07-4, 2,4-Dichlorofuro[3,2-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 956034-07-4, blongs to pyrimidines compound. Quality Control of 2,4-Dichlorofuro[3,2-d]pyrimidine
[0174] To a reaction flask were added compound 31-c (0.088 mmol), compound 31-b (according to the synthesisprocedure in the patent: WO 2011/079230 A2) (15 mg, 0.080 mmol), PdCl2(dppf) (3 mg, 0.004 mmol), 2 N aqueoussodium carbonate solution (0.12 mL, 0.24 mmol) and 1,4-dioxane (3 mL). Under nitrogen, the mixture was stirredovernight at 80C. After the reaction mixture was concentrated, the residue was diluted with water (15 mL), and theaqueous phase was extracted with dichloromethane (15 mL 3 2). The organic layers were combined and washedsuccessively with water and saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated to givecrude product 31-a (35 mg) which was used directly in the next reaction without further purification. LC-MS (ESI): m/z=248.1 [M+H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,956034-07-4, its application will become more common.
Reference:
Patent; Shanghai Yingli Science and Technology Co., Ltd; Shanghai Chemexplorer Co., Ltd.; XU, Zusheng; EP2860181; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia