Synthetic Route of 10244-24-3 ,Some common heterocyclic compound, 10244-24-3, molecular formula is C12H17ClN4O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
4,4 ‘ – (6-chloro-pyrimidine -2,4-diyl) two morpholine (210 mg, 0 . 74mmol), 3 – (2-amino-5-bromo-(trifluoromethyl) pyridin-3-yl) acrylic acid methyl ester (480 mg, 1 . 47mmol),were taken and then palladium acetate (34 mg, 0 . 15mmol), n-butyl, di (1-adamantyl) diphenylphosphinobiphenyl (80 mg, 0 . 22mmol), pinacone esterjoint boric acid (470 mg, 1 . 9mmol) and cesium carbonate (842 mg, 2 . 6mmol) were added to the toluene (10 ml) and methanol (10 ml) under the protection of nitrogen and the temperature was raised to 75 C reaction for 16 hours. adding water (50 ml), dichloromethane (100 ml) extraction, the organic phase with saturated salt water (60 ml) washing, drying by anhydrous sodium sulfate, concentrated, crude product by silica gel column chromatography (dichloromethane: methanol =20:1) purified title compound (320 mg, yield 87.6%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,10244-24-3, its application will become more common.
Reference:
Patent; Shandong Xuan Bamboo Pharmaceutical Technology Co., Ltd.; Wu, Yong qian; (49 pag.)CN105461714; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia