13 Sep 2021 News Introduction of a new synthetic route about 3029-64-9

Statistics shows that 3029-64-9 is playing an increasingly important role. we look forward to future research findings about 2,4,6-Trichloro-5-cyanopyrimidine.

Electric Literature of 3029-64-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3029-64-9, name is 2,4,6-Trichloro-5-cyanopyrimidine, molecular formula is C5Cl3N3, molecular weight is 208.43, as common compound, the synthetic route is as follows.

EXAMPLE IV 4,6-Dichloro-2-(1-cyano-1-methylethylamino)-5-pyrimidinecarbonitrile A stirred solution of 6.3 grams of 2,4,6-trichloro-5-pyrimidinecarbonitrile in 25 ml of acetone was cooled to -10°, and 2.5 grams of 2-amino-2-methylpropionitrile was added. With the reaction mixture at -10°, a solution of 1.3 grams of sodium hydroxide in 3.5 ml of water was added dropwise. Upon complete addition, the reaction mixture was stirred at -10° for 30 minutes. The acetone was removed under reduced pressure; the residue was extracted with diethyl ether, and the extract was separated and dried over magnesium sulfate. The extract was filtered, and the filtrate was evaporated under reduced pressure, yielding a residue. The residue was recrystallized from methylcyclohexane to give 3.1 grams of 4,6-dichloro-2-(1-cyano-1-methylethylamino)-5-pyrimidinecarbonitrile; mp, 154-158°. Analysis: Calculated for C9 H7 Cl2 N5: C,42.21; H,2.73; N,27.34; Found: C,42.26; H,2.92; N,27.35.

Statistics shows that 3029-64-9 is playing an increasingly important role. we look forward to future research findings about 2,4,6-Trichloro-5-cyanopyrimidine.

Reference:
Patent; FMC Corporation; US4092150; (1978); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia