Application of 24415-66-5, Adding some certain compound to certain chemical reactions, such as: 24415-66-5, name is 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine,molecular formula is C6H5ClN4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 24415-66-5.
A mixture of appropriate compound 8 (10 mmol), piperazine, (10 mmol) and K2CO3 (12 mmol) in 1,4-dioxane was reflux at 100 C for 3 h. The reaction mixture was cooled down to room temperature. The reaction mixture was filter and washed with 1,4-dioxane. The filtrate was concentrated and dried by vacuum. 4.1.5.1. 5-methyl-7-(piperazin-1-yl)-[1,2,4]triazolo[1,5-a]pyrimidine (9). Yellowish (Yield 70%). 1H NMR (400 MHz, CDCl3) delta 8.23 (s, 1H, Triazolopyrimidine-Hb), 6.09 (s, 1H, Triazolopyrimidine-Ha), 3.73 (4H, Piperazine), 3.63 (s, 1H, -NH), 3.05 (4H, Piperazine), 2.51 (s, 3H, Triazolopyrimidine-CH3).; 13C NMR (101 MHz, CDCl3) delta 164.7, 157.2, 153.9, 150.7, 94.5, 49.2, 45.8, 25.2.
According to the analysis of related databases, 24415-66-5, the application of this compound in the production field has become more and more popular.
Reference:
Article; Kumar, Jitendra; Meena, Poonam; Singh, Anju; Jameel, Ehtesham; Maqbool, Mudasir; Mobashir, Mohammad; Shandilya, Ashutosh; Tiwari, Manisha; Hoda, Nasimul; Jayaram; European Journal of Medicinal Chemistry; vol. 119; (2016); p. 260 – 277;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia