Application of 1197953-49-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1197953-49-3, name is (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide. This compound has unique chemical properties. The synthetic route is as follows.
Add compound 13 to a 25 mL single-mouth bottle with magnetic stirrer and condenser(160 mg, 0.61 mmol), compound 7 (192 mg, 0.61 mmol)And ethylene glycol monomethyl ether (4mL), stir and dissolve,Add hydrogen chloride isopropanol solution (0.91 mmol, 0.18 mL, 5 M) dropwise.The temperature was raised to 120 C under a nitrogen atmosphere and stirred to react overnight. Cool to room temperature,Add water(10 mL) and saturated sodium bicarbonate (5 mL), dichloromethane (15 mL×3)The organic phase was combined, washed with saturated brine, dried over anhydrous sodiumConcentrated, the residue was passed through a silica gel column to give a white solid200 mg, the yield was 60.7%.
According to the analysis of related databases, 1197953-49-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Shenzhen Tajirui Bio-pharmaceutical Co., Ltd.; Wang Yihan; Li Huanyin; (49 pag.)CN109851638; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia