Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 10320-42-0, name is 2-Chloro-5-nitropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 2-Chloro-5-nitropyrimidine
Step D: tert-butyl ethyl but-3~yn-1-yl(5-nitropvrimidin-2-yl)propanedioate: A suspension of NaH (60 percent, 2.5 g, 62.4 mmol) in 100 mL ofDMF was added tert-butyl ethyl but-3-yn-1-ylpropanedioate (15 g, 62.4 mmol) drop-wise at 25 oc. The mixture was stirred at 40 oc for 30minutes and 2-chloro-5-nitropyrimidine (10.0 g, 62.4 mmol) in 50 mL ofDMF was addeddropwise. The resulting suspension was stirred at 50 oc for 2 hours and diluted with 500 mL ofEtOAc. The mixture was washed with water (3 x 100 mL), brine, dried over anhydrous Na2S0430 and concentrated. The residue was purified by column chromatography (Petroleum ether :EtOAc = 10 : 1) to afford the title compound; MS m/z 364 (M+ 1)+.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 10320-42-0, 2-Chloro-5-nitropyrimidine.
Reference:
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; BLIZZARD, Timothy; CHOBANIAN, Harry; DE JESUS, Reynalda; DING, Fa-Xiang; DONG, Shuzhi; GUDE, Candido; KIM, Dooseop; TANG, Haifeng; WALSH, Shawn; PIO, Barbara; JIANG, Jinlong; WO2013/28474; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia