Electric Literature of 28485-17-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 28485-17-8, name is 5-Carbethoxyuracil, molecular formula is C7H8N2O4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a 100 ml three-necked flask was added ethyl uracil-5-carboxylate (2.2 g, 11.95 mmol)N, N-dimethylaniline (2 g, 16.50 mmol).Under ice bath, phosphorus oxychloride (9.2 g, 60 mmol) was gradually added and stirred continuously.After the addition of 10 minutes, gradually heating 110 C, and insulation 3h reaction.The reaction solution was slowly poured into an ice-water mixture (100 ml) and quenched and kept at a temperature below 5 C. And extracted twice with ethyl acetate (200 ml).The organic phases were combined, washed with saturated brine, dried and concentrated to give the crude product.The crude product was purified by column chromatography to give 1.8 g of solid in 68% yield.
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Reference:
Patent; SUZHOU WANGSHAN WANGSHUI BIOMEDICAL CO LTD; TOPHARMAN SHANGHAI CO LTD; SHANDONG TOPHARMAN PHARMACEUTICAL CO LTD; TIAN, GUANGHUI; LI, JUNQI; (17 pag.)CN104650045; (2017); B;,
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