Adding a certain compound to certain chemical reactions, such as: 13223-43-3, 5,7-Dimethoxy-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 13223-43-3, blongs to pyrimidines compound. Recommanded Product: 13223-43-3
2-Amino-5,7-dimethoxy [1,2,4] triazolo [1,5-a] pyrimidine (25.4g, 0.13mol) Add to 137g of dichloromethane, After stirring, 4-dimethylaminopyridine (0.006 g, 0.05 mmol) and 2-methoxy-4-(trifluoromethyl)-pyridine-3-sulfonyl chloride (27.5 g, 0.1 mol), After stirring for 30 minutes, Triethylamine (13.1 g, 0.13 mol) was added dropwise at room temperature. Finally, the temperature was raised to 35 C for 3 h. The mixture was then treated with 4N HCl (60g), was stirred at 25 1 hour, cooled to 10 , filtered, washed with water, washed with methanol and dried to give 40.8 g of pyroxsulam, 94% yield, 98.5% purity (HPLC).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,13223-43-3, 5,7-Dimethoxy-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine, and friends who are interested can also refer to it.
Reference:
Patent; Changzhou Woteng Chemical Technology Co., Ltd.; Cao Wei; (5 pag.)CN108892671; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia