Application of 355806-00-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 355806-00-7 as follows.
Example 8- (Preparation in Toluene/H20) A 250ML flask equipped with a mechanical stirrer was charged with toluene (25 mL), 5 g t-Butyl-Rosuvastatin, 25 mL H20, 0.75 g of TBAB (tetrabutylammonium bromide) (15% W/W) and 1. 86 g NAOH pellets. The mixture was stirred at ambient temperature for 2 hours. The phases were separated in an apparatus funnel. Traces of toluene in the aqueous phase were distilled off under reduced pressure at 40C to obtain a thick slurry (36.0 g). To this slurry was added 49.5 g CaCl2 1N dropwise. The solution was stirred at ambient temperature for 1.5 hours, filtered and washed with 10 mL of water to get a powdery compound.; Example 10- (preparation in Toluene/H20, 5EQ NAOH)) A 250ML flask equipped with a mechanical stirrer was charged with toluene (25 mL), 5 g t-Butyl-Rosuvastatin, 25 mL H2O, 0.75 g TBAB (tetrabutylammonium bromide) (15% w/w) and 1.86 g NAOH pellets. The mixture was stirred at ambient temperature for 2 hours. The phases were separated in a separation funnel. Traces of toluene in the aqueous phase were distilled off under reduced pressure at 40C to obtain a slurry (24.0 g). Make-up of water was done (26 mL) at the end of the evaporation to obtain a clear solution. To this solution was added 3.3 g CaCl2 IN L0 ML water dropwise. The solution was stirred at ambient temperature for 2 hours, filtered and washed with LOML of water to get a powdery compound.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,355806-00-7, its application will become more common.
Reference:
Patent; TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.; WO2005/23778; (2005); A2;,
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