Synthetic Route of 1004-40-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1004-40-6, name is 6-Amino-4-hydroxy-2-mercaptopyrimidine. A new synthetic method of this compound is introduced below.
General procedure: Synthesis of product (4a-o): A mixture of, 2-hydroxy-1,4-naphthoquinone (0.174 g,1 mmol), aromatic aldehydes (1 mmol), 6-amino-2-thiouracil (0.143 g, 1 mmol) and 10 mLEtOH in a 50 mL flask was heated at reflux for 12-15 hours. After reaction completion(monitored by TLC, ethyl acetate/n-hexane, 1:1), the reaction mixture was cooled to roomtemperature and filtered to give the crude product. Then the solid was washed with ethanolto give product (4) in good to high yields.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1004-40-6, 6-Amino-4-hydroxy-2-mercaptopyrimidine, and friends who are interested can also refer to it.
Reference:
Article; Hosseini, Fahimeh Sadat; Bayat, Mohammad; Journal of Sulfur Chemistry; vol. 39; 5; (2018); p. 483 – 494;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia