Adding a certain compound to certain chemical reactions, such as: 10397-13-4, 4-(4,6-Dichloropyrimidin-2-yl)morpholine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C8H9Cl2N3O, blongs to pyrimidines compound. COA of Formula: C8H9Cl2N3O
5 – azaspiro [2.4] heptane -7 – alcohol (0.4g, 3 . 53mmol) and 4 – (4, 6 – dichloro pyrimidine -2 – yl) morpholine (640 mg, 2 . 72mmol) is dissolved in isopropanol (15 ml), add DIPEA (700 mg, 5 . 44mmol), raising the temperature to 80 C, stirring overnight, the reaction solution concentration, for purification column chromatography (petroleum ether: ethyl acetate=1:1), shall be 5 – (6 – chloro -2 – morphine linlin base pyrimidine -4 – yl) -5 – azaspiro [2.4] heptane -7 – alcohol (400 mg, 49%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,10397-13-4, 4-(4,6-Dichloropyrimidin-2-yl)morpholine, and friends who are interested can also refer to it.
Reference:
Patent; Shanghai Huilun Life Technology Co., Ltd.; Cheng Jianjun; Qin Jihong; (41 pag.)CN104557871; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia