Application of 332133-92-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.332133-92-3, name is 4-(Tributylstannyl)pyrimidine, molecular formula is C16H30N2Sn, molecular weight is 369.1328, as common compound, the synthetic route is as follows.
A solution of compound 5 (175 mg, 0.19 mmol), compound 51 (103 mg, 0.28 mmol), Pd(PPh3)4 (22 mg, 0.02 mmol) in 1,4-dioxane (4 mL) was microwaved at 100 C for 40 minutes, LC-MS showed that the start materials was consumed up, stopped the reaction, poured into a mixture of DCM (60 mL) and H20 (50 mL), filtered through a pad of celite, the organic layer was separated, washed with brine, dried over anhydrous Na2S04, concentrate in vacuo, the residue was purified by column (DCM/MeOH 100/1 to 40/1) to give compound 52 (9 mg, 11% yield) as a white solid. MS (ESI) (M/Z): [M+H]+ =402.1
The chemical industry reduces the impact on the environment during synthesis 332133-92-3, I believe this compound will play a more active role in future production and life.
Reference:
Patent; ZHANG, Hai-Jun; (63 pag.)WO2018/217439; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia