Related Products of 1088994-22-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1088994-22-2, name is 5-Methyl-2-(pyrimidin-2-yl)benzoicacid, molecular formula is C12H10N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
1- (5- (4-fluorophenyl) pyrimidin-2-yl) -1,4-diazepan (0.163g, 0.6mmol), 5- methyl-2- (pyrimidin-2 yl) benzoic acid 0.128g, 0.6mmol) and anhydrous N, N- dimethylformamide (5mL) were added sequentially to a 50mL round bottom flask, and then at -20 deg.] C, slowly added sequentially N, N- two diisopropylethylamine (0.32mL, 1.8mmol) and 1-propyl phosphoric acid cyclic anhydride (1.336g, 2.1mmol) in ethyl acetate in 50% wt solution, the reaction solution after 1 hour reaction, the reaction temperature was raised to 50 20 hours and then at room temperature for 24 hours trans. To stop the reaction, under ice-cooling, to the reaction mixture was slowly added water (20 mL) and a saturated aqueous solution of sodium hydroxide (5ml) to the reaction solution to pH 7-8, and (100mL × 2) and extracted with methylene chloride, The combined dichloromethane layer was washed with water (50mL × 3) and saturated brine (10 mL), dried organic layer was separated, dried over anhydrous sodium sulfate. The filtrate was concentrated under reduced pressure, the resulting residue was purified by silica gel column chromatography (methylene chloride / methanol (v / v) = 50/1) to give the title compound as a yellow via solid (57mg, 20.1%).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1088994-22-2, 5-Methyl-2-(pyrimidin-2-yl)benzoicacid.
Reference:
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd.; Jinchuan, Fei; Gao, Heng; Zhang, Ji; Zhang, Yingjun; (84 pag.)CN105461699; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia