Adding a certain compound to certain chemical reactions, such as: 696-07-1, 5-Iodouracil, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C4H3IN2O2, blongs to pyrimidines compound. HPLC of Formula: C4H3IN2O2
General procedure: In a typical experiment Pd(OAc)2, triphenylphosphine, iodouracil derivatives (1, 5), amine nucleophiles (a-g) and triethylamine were used in the same amount as above and were dissolved in 10mL of DMF under argon in a 100mL autoclave. The atmosphere was changed to carbon dioxide and the autoclave was pressurized to the given pressure with carbon monoxide. (Caution: High pressure carbon monoxide should only be used with adequate ventilation (hood) using CO sensors as well.) The reaction was conducted for the given reaction time upon stirring at 50C. After the given reaction time the reaction mixture was cooled to room temperature and the autoclave was carefully depressurized in a well-ventilated hood. The product mixture was analysed by GC and GC-MS. The work-up of the reaction mixture was identical to that discussed for the atmospheric experiments. 3.4.1 5-(N-tert-Butylglyoxylamido)uracil (3a) Yield: 175mg (73%), Off white powder, m.p. 270-271C; Rf (15% MeOH/CHCl3) 0.65. deltaH (500MHz, DMSO-d6) 11.82 (1H, br s, NH), 11.42 (1H, br s, NH), 8.20 (1H, s, NHCH), 7.98 (1H, s, CONH), 1.31 (9H, 3 x (CH)3). deltaC NMR (125.7MHz) 186.6, 165.7, 161.3, 150.9, 150.6, 108.8, 51.1, 28.7. IR (KBr, nu (cm-1)): 3375 (NH), 1734, 1700, 1669 (CO), 1653 (Amide I.), 1616 (C=C), 1499 (Amide II.); MS m/z (rel. int.): 238 (100, [M-H]-), MS/MS (rel. int.) 238 (19), 223 (10), 195 (32), 123 (8), 111 (100).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,696-07-1, 5-Iodouracil, and friends who are interested can also refer to it.
Reference:
Article; Kollar, Laszlo; Varga, Marta Georgina; Doernyei, Agnes; Takacs, Attila; Tetrahedron; vol. 75; 33; (2019); p. 4632 – 4639;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia