Adding a certain compound to certain chemical reactions, such as: 51674-77-2, 4-Chloropyrido[3,2-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C7H4ClN3, blongs to pyrimidines compound. HPLC of Formula: C7H4ClN3
Intermediate 9 (700 mg, 2.06 mmol), 2-(dimethylamino)-l-(piperazin-l-yl)- ethanone (500 mg), n-BuOH (10 mL) and DIPEA (2 mL) were combined in a sealed tube and heated at 130C for 13 days. The reaction mixture was cooled, concentrated onto silica and purified by column chromatography (Si02, 0-10% MeOH in EtOAc) to give a white solid. This material, MeOH (8 mL) and 2M HC1 in Et20 (4 mL) were combined and stirred at r.t. for 2 days. The reaction mixture was concentrated in vacuo to give a yellow foam. A portion of this material (50 mg, 0.12 mmol), rc-BuOH (6 mL), DIPEA (1 mL) and 4-chloropyrido[3,2-c/]pyrimidine (50 mg, 0.25 mmol) were combined in a sealed tube and heated at 130C for 16 h. The reaction mixture was then concentrated to dryness and purified by preparative HPLC to give the title compound (28 mg, 43%) as a white solid. deltaEta (DMSO-
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia