Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 696-07-1, name is 5-Iodouracil. This compound has unique chemical properties. The synthetic route is as follows. category: pyrimidines
5-bromo- or 5-iodouracil (1.0 equiv.) is suspended in N,N-dimethylaniline, treated with phosphorus oxychloride (10.0 equiv.) and stirred for 90 minutes at 125 C. After cooling to room temperature, excess phosphorus oxychloride is removed under vacuum. The residue is poured into ice-water. After 2 hours the crystals that have formed are filtered off at the pump and washed with water. Next, the crystals are dissolved in ethyl acetate. The organic phase is washed with saturated sodium hydrogen carbonate solution and saturated sodium sulphite solution and dried over sodium sulphate. After removal of the solvent the chromatographic purification is performed.; Starting from 5-iodouracil (10g, 42 mmol)) and N,N-dimethylaniline (11.0 mL), the desired product is obtained according to procedure 1 in 92% yield (10.6 g) after chromatographic purification (silica gel, dichloromethane). 1H-NMR (400 MHz, CDCl3): delta 8.90 (s, 1H).
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Reference:
Patent; Lucking, Ulrich; Nguyen, Duy; Von Bonin, Arne; Von Ahsen, Oliver; Kruger, Martin; Briem, Hans; Kettschau, Georg; Prien, Olaf; Mengel, Anne; Konrad, Krolikiewicz; Boemer, Ulf; Bothe, Ulrich; Hartung, Ingo; US2007/232632; (2007); A1;,
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