Reference of 49844-90-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 49844-90-8, name is 4-Chloro-2-(methylthio)pyrimidine, molecular formula is C5H5ClN2S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Hydroiodic acid (57 %) was added to 4-chloro-(2-methylthio) pyrimidine at about 30C and stirred for about 72 hours in dark. The reaction mixture was filtered through sintered funnel, dissolved in water and basified with sodium bicarbonate and then extracted with chloroform. The chloroform layer was washed with aqueous sodium thiosulphate solution, water, brine, dried over anhydrous sodium sulphate, concentrated and crystallized from hexane to form the title product.
According to the analysis of related databases, 49844-90-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; RANBAXY LABORATORIES LIMITED; WO2007/60618; (2007); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia