Reference of 16097-63-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 16097-63-5 as follows.
To a mixture of 4 ml of water, 1.4 g of sodium cyanide and 0.29 g of 1, 4-diazabicyclo [2.2.2] octane, 20 ml of dimethyl sulfoxide and the crude product were added at 00C. This mixture was stirred for 1 hour. The reaction mixture was poured into water and then extracted three times with tert-butyl methyl ether. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate and then concentrated. The residue was subjected to silica gel column chromatography to obtain 3.2 g of 2-methylthio-6- trifluoromethylpyrimidine-4-carbonitrile . 2-methylthio-6-trifluoromethylpyrimidine-4-carbonitrile1H-NMR: 2.63(s,3H), 7.53(s,lH)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16097-63-5, its application will become more common.
Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; MIZUNO, Hajime; WO2010/134478; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia