Related Products of 16097-60-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 16097-60-2, name is 2-Amino-4-chloro-6-(trifluoromethyl)pyrimidine. A new synthetic method of this compound is introduced below.
Under an ice bath, add 2-amino-4-chloro-6-trifluoromethylpyrimidine (197.0 mg, 1.0 mmol), N-tert-butoxycarbonyl-1,3-propanediamine (208.8 mg, 1.2 mmol) , Dissolved in methanol (8.0 ml), and stirred at reflux overnight. The solvent was recovered under reduced pressure to obtain a residue, which was purified by silica gel column chromatography. PE: EA (5: 1-2: 1) was first used as eluent to obtain 1-36 as a white solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,16097-60-2, 2-Amino-4-chloro-6-(trifluoromethyl)pyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; Zhejiang University; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Liu Tao; Li Jia; Dong Xiaowu; Zhou Yubo; Hu Yongzhou; Wang Peipei; Jin Tingting; Liu Jieyu; Hu Xiaobei; (51 pag.)CN110872277; (2020); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia