Electric Literature of 695-87-4, Adding some certain compound to certain chemical reactions, such as: 695-87-4, name is 5-Methoxypyrimidin-4(1H)-one,molecular formula is C5H6N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 695-87-4.
EXAMPLE 4 4-Chloro-5-methoxypyrimidine (VII) Materials: Procedure: To a stirred slurry of 4-hydroxy-5-methoxypyrimidine in toluene (171 mL) was added DIPEA and POCl3 at room temperature under nitrogen atmosphere, The reaction mixture was stirred for about 1-2 hours at 60 to 70 C. under nitrogen atmosphere to complete the reaction. The reaction was quenched by adding 90 mL of 1.55N NaOH at 5 to 8 C. and the aqueous phase was separated. The organic layer was washed with saturated NaHCO3 solution (31 mL) and polish filtered. Concentration of the intermediate was determined by HPLC quantitation. This 0.37 to 0.43M solution of chloromethoxypyrimidine was used without further purification,
According to the analysis of related databases, 695-87-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Bristol-Myers Squibb Company; US5550239; (1996); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia