Adding a certain compound to certain chemical reactions, such as: 38275-43-3, 2-(Methylthio)pyrimidine-5-carbonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 38275-43-3, blongs to pyrimidines compound. COA of Formula: C6H5N3S
To a solution of 2-(methylthio)pyrimidine-5-carbonitrile (Biofine International Inc.) (390 mg, 2.58 mmol) in 1 ,4-dioxane (3 mL), N-methyl-1-(pyridin-4-yl)methanamine (Fisher Scientific International – Maybridge) (789 mg, 2.50 mmol) was added at rt. The resulting reaction mixture was heated in the microwave oven at 170C for 10 h. Subsequently the solvent was evaporated at high vacuum and the remaining oily residue subjected to purification by flash chromatography (ISCO CombiFlash Rf; 80 g silicagel, dichlormethane/methanol) to give 2- {methyl{pyridin-4-ylmethyl)amino)pyrimidine-5-carbonitrile (404 mg, 1.65 mmol, 64 % yield) as yellow powder. HPLC RT 1.323 min (Method A); ESI S [ +1] + 226
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,38275-43-3, its application will become more common.
Reference:
Patent; NOVARTIS AG; HEBACH, Christina; KALLEN, Joerg; NOZULAK, Joachim; TINTELNOT-BLOMLEY, Marina; WIDLER, Leo; WO2013/80120; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia