Related Products of 32998-03-1 , The common heterocyclic compound, 32998-03-1, name is 2,6-Dichloro-N-methylpyrimidin-4-amine, molecular formula is C5H5Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
EXAMPLE 5 2,6-bis-(2–Hydroxyethyl)methylamino-4-methylaminopyrimidine (V) A mixture of 2,6-dichloro-4-methylamino-pyrimidine (III, EXAMPLE 1, 1.78 g) and 2-(methylamino)ethanol (IV, 25 ml) is heated under reflux for about 18 hours, then is allowed to cool and is diluted with ethyl acetate (100 ml). The mixture is washed with aqueous potassium bicarbonate (0.5N), water (4*25 ml) and with saline (50 ml). The aqueous phases are backwashed with ethyl acetate. The organic extracts are combined, dried and concentrated to give the title compound, NMR (CDCl3) 4.82, 3.8, 3.68, 3.11, 3.00 and 2.84delta; CMR (CDCl3) 164.0, 161.76, 71.16, 63.08, 62.47, 52.64, 36.91, 36.49 and 28.35delta.
The synthetic route of 32998-03-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; The Upjohn Company; US5502187; (1996); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia