Electric Literature of 1060815-89-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1060815-89-5, name is 7H-Pyrrolo[2,3-d]pyrimidine-5-carbaldehyde, molecular formula is C7H5N3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a O C solution of 7H-pyrrolo[2,3-djpyrimidine-5-carbaldehyde (5.41 g, 36.8mmol) and cesium carbonate (13.18 g, 40.4 mmol) in DMF (147 ml) was added tert-butyl 2-bromoacetate (5.90 ml, 40.4 mmol). The mixture was allowed to warm up to RT byremoving from ice bath. The reaction was stirred for 2 hs. The reaction was poured ontoice water (500 mL) and EtOAc (300 mL) mixture. The product was extracted in theEtOAc. The layers were separated and the aqueous phase was extracted a second time with EtOAc (2x 150 mL). The combined EtOAc layers were washed with brine. The organic layer was collected and dried over sodium sulfate and concentrated undervacuum. The crude product was purified by silica gel chromatography to get tert-butyl 2-(5-formyl-7H-pyrrolo[2,3-djpyrimidin-7-yl)acetate 6.60 g (69%) as clean product. ESIMS(-): MS m/z 262.0.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1060815-89-5, 7H-Pyrrolo[2,3-d]pyrimidine-5-carbaldehyde.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; MILLER, Michael Matthew; ALLEN, Martin Patrick; LI, Ling; BOWSHER, Michael S.; GILLIS, Eric P.; MULL, Eric; ZHAO, Qian; SUN, Li-Qiang; LANGLEY, David R.; SCOLA, Paul Michael; (214 pag.)WO2017/176608; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia