Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 22404-46-2, name is 4-Chloro-N-methylpyrimidin-2-amine. This compound has unique chemical properties. The synthetic route is as follows. category: pyrimidines
To tert-butyl 4- (4- ( (E) -2- (2-methoxy-5- (4, 4, 5, 5- tetramethyl-1, 3, 2-dioxaborolan-2-yl) pyridin-3- yl) vinyl) phenyl) piperazine-1-carboxylate (191 mg, 0.37 iranol) and 4-chloro-N-methylpyrimidin-2-amine (79 mg, 0.55 mmol) in toluene (4 mL) and ethanol (2 itiL) under nitrogen was added 2M aqueous potassium carbonate (0.55 mL, 1.10 mmol) followed by palladium tetrakis (triphenylphosphine) (17 mg, 14.6 mumol) . The reaction mixture was heated at 120 0C overnight. The reaction mixture was partitioned between EtOAc (30 mL) and water (50 mL) . The organic layer was dried (MgSO4) , filtered and concentrated and the residue was purification by column chromatography (EtOAc) to give the title compound (168 mg, 91%) as a yellow solid. EPO
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Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2007/27528; (2007); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia