Adding a certain compound to certain chemical reactions, such as: 289042-10-0, N-(5-((Diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines
40.0 g of compound (DPPO) and 500 ml of THF were added to a 1000 ml four-necked flask.Stir and dissolve, and replace with nitrogen three times.Under nitrogen protection, the internal temperature was lowered to -75.0 C, and 79.0 ml of 1.0 M NaHMDS/THF solution was slowly added dropwise.Control the internal temperature -80.0 C ~ -75.0 C, after the completion of the addition of the reaction, 2.0 h,After the end of the heat preservation reaction, the internal temperature is controlled from -80.0 C to -75.0 C.The compound (D7) THF solution (D7: 23.1 g, THF: 20 ml) was added dropwise, and the reaction was kept for 1.0 h after the dropwise addition;The sample was controlled until the residual of the compound (DPPO) in the reaction solution was ?1.0%, and the reaction was completed. Rise to room temperature,The reaction was quenched by adding 100 ml of a saturated ammonium chloride solution. After quenching, the material was subjected to distillation under reduced pressure at an external temperature of 50.0 C.Vacuum degree ? -0.09MPa, after evaporation to dryness, add 400.0g of toluene to dissolve,It was washed with water, concentrated, and crystallized from 400.0 g of methanol to give compound (R1) 30.0 g.
The synthetic route of 289042-10-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Zhejiang Yongtai Pharmaceutical Co., Ltd.; Wang Xuejin; Xu Xubing; Zhang Chong; Chen Hao; (18 pag.)CN109824606; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
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