Reference of 29458-38-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 29458-38-6, name is 6-Methoxypyrimidine-2,4(1H,3H)-dione. A new synthetic method of this compound is introduced below.
A stirred solution of 6-methoxypyrimidine-2, 4-diol 29 (7 g, 49.30 mmol) in phosphoryl chloride (150 mL) under argon atmosphere was heated to reflux for 4 h. The reaction was monitored by TLC; after completion of the reaction, the excess phosphoryl chloride was removed in vacuo. The residue was diluted with ice-cold water (100 mL) and extracted with EtOAc (2 x 100 mL). The combined organic extracts were washed with aqueous saturated NaHC03 solution (50 mL) followed by water (50 mL), dried over sodium sulfate, filtered and concentrated in vacuo to obtain the crude compound 30 (3 g, 34%) as colorless oily liquid. TLC: 10% EtOAc/ hexanes (Rf. 0.7); 1H-NMR (CDC13, 500 MHz): delta 6.72 (s, 1H), 4.03 (s, 3H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,29458-38-6, 6-Methoxypyrimidine-2,4(1H,3H)-dione, and friends who are interested can also refer to it.
Reference:
Patent; INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION; ARNOLD, Lee Daniel; MAAG, Hans; TURNER, JR., William W.; (274 pag.)WO2016/168619; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
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