3934-20-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 3934-20-1 as follows.
Phenylboronic acid (1 eq) and 2,4-dichloropyrimidine (1 eq) were added to tetrahydrofuran, to which 10% sodium bicarbonate (1 eq) was added. Nitrogen was bubbled into the mixture to remove oxygen while the reaction mixture was well stirred. 0.05 equivalent of palladium tetrakis was added to the mixture and stirred well. The mixture was then refluxed under a stream of nitrogen for 24 hours. After the reaction was complete, the mixture was worked up with ethyl acetate and water to give a crude yellow solid. The solid was purified by column chromatography to give white solid crystals. TLC was observed at Rf: 05 (ethyl acetate: hexane)
The chemical industry reduces the impact on the environment during synthesis 3934-20-1, I believe this compound will play a more active role in future production and life.
Reference:
Patent; CHUNGNAM NATIONAL UNIVERSITY INDUSTRY & ACADEMIC COOPERATION (IAC); JUNG, SANG HUN; WOO, SUN HEE; KIM, SANG KYUM; JEON, EUN SEOK; LEE, YOU JUNG; MANICKAM, MANOJ; JALANI HITESHKUMAR, HITESHKUMAR; SHARMA, NITI; (234 pag.)KR2015/111825; (2015); A;,
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