So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Gupta, Vijay; Sahu, Debashish; Jain, Shailja; Vanka, Kumar; Singh, Ravi P. researched the compound: 5-Methylfuran-2(3H)-one( cas:591-12-8 ).Computed Properties of C5H6O2.They published the article 《Diastereoselective multi-component tandem condensation: synthesis of 2-amino-4-(2-furanone)-4H-chromene-3-carbonitriles》 about this compound( cas:591-12-8 ) in Organic & Biomolecular Chemistry. Keywords: amino furanone chromene carbonitrile diastereoselective synthesis; multicomponent tandem Knoevenagel Pinner vinylogous Michael condensation sequence. We’ll tell you more about this compound (cas:591-12-8).
A general strategy for a one-pot stereoselective synthesis of 2-amino-4-(2-furanone)-4H-chromene-3-carbonitriles by reaction of salicylaldehyde, malononitrile and butenolides via a tandem Knoevenagel/Pinner/vinylogous Michael condensation is presented. The β,γ-butenolides gave a syn-selective MCR adduct with a dr up to 11.5 : 1. The mechanistic insight into the MCR was obtained by DFT calculations
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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia