The important role of 3073-77-6

Adding a certain compound to certain chemical reactions, such as: 3073-77-6, 2-Amino-5-nitropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 3073-77-6, blongs to pyrimidines compound. 3073-77-6

Example 83. iV-[4-(3-Pyrrolidiii-l-yl-propane-l-sulfonyl)-phenvI1-pyrimidine-2,5-diamine (52); [0244] To a solution of 2-amino-5-nitropyrimidine (350 mg, 2.5 mmol) in 20 mL anhydrous 1,4-dioxane were added intermediate 51 described in Example 82 (1.25 g, 3.76 mmol) in 5 mL anhydrous 1,4-dioxane, Xantphos, (289 mg, 0.5 mmol), Pd2(dba)3 (229 mg, 0.25 mmol) and Cs2CO3 (1.63 g, 5 mmol). The reaction mixture was stirred at 1000C for 5 h under argon. The reaction mixture was diluted with methanol and CH2Cl2 (5 mL each) then filtered. The filtrate was washed with brine. The organic phase was dried (Na2SO4) and the solvent was removed. The residue was dissolved in methanol and ethyl EPO acetate (2 mL each) and diluted with 20 mL hexane. The precipitated yellow-brown solid, was isolated by filtration and dried in vacuo (800 mg). The crude product was hydrogenated in 20 mL methanol using Pd/C (10 %, 500 mg) for 2 h. The palladium catalyst was removed by filtration, and the solvent was evaporated. The residue was dried in vacuo to yield the title compound (550 mg, 73 %), which was used without further purification.[0245] 1H NMR (DMSOd6): delta 1.60-1.68 (m, 6H)3 2.32 (m, 4H), 2.39 (m, 2H), 3.19 (m, 2H), 5.02 (bs, 2H), 7.68 (d, J= 9.0 Hz, 2H), 7.87 (d, J= 9.0 Hz, IH), 8.02 (s, 2H), 9.68 (s, IH). MS (ES+): m/z = 362 (M+H)+.

With the rapid development of chemical substances, we look forward to future research findings about 3073-77-6.

Reference:
Patent; TARGEGEN, INC.; WO2006/101977; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia