The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride( cas:148-51-6 ) is researched.Electric Literature of C8H12ClNO2.Patzer, Emmons M.; Hilker, Doris M. published the article 《New reagent for vitamin B6 derivative formation in gas chromatography》 about this compound( cas:148-51-6 ) in Journal of Chromatography. Keywords: vitamin B6 gas chromatog; pyridoxine trifluoroacetamide derivative gas chromatog. Let’s learn more about this compound (cas:148-51-6).
Gas-chromatog. separation of 4 vitamin B6 derivatives consisted of converting them into hemiacetals with EtOH, refluxing at 125° for 15 min, evaporating the excess EtOH at 70° under N, and adding the new reagent N-methylbistrifluoroacetamide [685-27-8], followed by refluxing at 125° for 20 min and injecting the samples onto a column packed with 5% silicone oil on Chromosorb P and using flame ionization detection. The compounds derivatized were pyridoxine-HCl (I) [58-56-0], pyridoxamine-di-HCl [524-36-7], deoxypyridoxine-HCl [148-51-6] and pyridoxal-HCl [65-22-5]. The min. detectable amount is ∼250 ng. The procedure is rapid, clean, and simple.
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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia