Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 63234-80-0, name is 3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one. This compound has unique chemical properties. The synthetic route is as follows. 63234-80-0
Example 3 3-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)ethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one 3-(2-chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (120 mg, 0.53 mmol), the product of Reference Example 1(116 mg, 0.53 mmol), potassium carbonate (219 mg, 1.59 mmol), potassium iodide (88 mg, 0.53 mmol) and acetonitrile (5 ml) were added to the flask and the mixture was stirred at 85¡ã C. overnight. The reaction mixture was concentrated and subjected to column chromatography to obtain a white solid (120 mg, yield: 55percent). 1HNMR (300 MHz, DMSO-d6): delta ppm 7.69 (d, 1H), 7.61 (d, 1H), 7.40 (d, 1H), 7.27 (t, 1H), 6.89 (d, 1H), 3.78 (t, 2H), 3.07 (brs, 4H), 2.75 (t, 2H), 2.68 (brs, 4H), 2.63 (t, 2H), 2.42 (t, 2H), 2.22 (s, 3H), 1.85 (m, 2H), 1.76 (m, 2H). ESI-MS (m/z): 409.1 [M+H]+.
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Reference:
Patent; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU VIGONVITA LIFE SCIENCES CO., LTD.; TOPHARMAN SHANDONG CO., LTD.; JIANG, Hualiang; WANG, Zhen; LI, Jianfeng; ZHANG, Rongxia; HE, Yang; LIU, Yongjian; BI, Minghao; LIU, Zheng; TIAN, Guanghui; CHEN, Weiming; YANG, Feipu; WU, Chunhui; WANG, Yu; JIANG, Xiangrui; YIN, Jingjing; WANG, Guan; SHEN, Jingshan; (70 pag.)US2017/158680; (2017); A1;,
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