The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Piperidin-4-amine dihydrochloride(SMILESS: NC1CCNCC1.[H]Cl.[H]Cl,cas:35621-01-3) is researched.Category: benzofurans. The article 《Polyamine Analog Regulation of NMDA MK-801 Binding: A Structure-Activity Study》 in relation to this compound, is published in Journal of Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:35621-01-3).
A series of analogs and homologs of spermine were synthesized, and their impact on MK-801 binding to the N-methyl-D-aspartate (NMDA) receptor was evaluated. These tetraamines encompass both linear and cyclic compounds The linear mols. include norspermine, N1,N11-diethylnorspermine, N1,N12-bis(2,2,2-trifluoroethyl)spermine, homospermine, and N1,N14-diethylhomospermine. The cyclic tetraamines consist of the piperidine analogs N1,N3-bis(4-piperidinyl)-1,3-diaminopropane, N1,N4-bis(4-piperidinyl)-1,4-diaminobutane, N1,N4-bis(4-piperidinylmethyl)-1,4-diaminobutane, and N1,N4-bis[2-(4-piperidinyl)ethyl]-1,4-diaminobutane and the pyridine analogs N1,N3-bis(4-pyridyl)-1,3-diaminopropane, N1,N4-bis(4-pyridyl)-1,4-diaminobutane, N1,N4-bis(4-pyridylmethyl)-1,4-diaminobutane, and N1,N4-bis[2-(4-pyridyl)ethyl]-1,4-diaminobutane. This structure-activity set makes it possible to establish the importance of charge, intercharge distance, and terminal nitrogen substitution on polyamine-regulated MK-801 binding in the NMDA channel. Four families of tetraamines are included in this set: norspermines, spermines, homospermines, and tetraazaoctadecanes. Calculations employing a SYBYL modeling program revealed that the distance between terminal nitrogens ranges between 12.62 and 19.61 Å. The tetraamines are constructed such that within families cyclics and acyclics have similar lengths but different nitrogen pKa’s and thus different protonation, or charge, states at physiol. pH. The pKa values for all nitrogens of each mol. and its protonation state at physiol. pH are described. The modifications at the terminal nitrogens include introduction of Et and β,β,β-trifluoroethyl groups and incorporation into piperidinyl or pyridyl systems. The studies clearly indicate that polyamine length, charge, and terminal nitrogen substitution have a significant effect on how the tetraamine regulates MK-801 binding to the NMDA receptor. Thus a structure-activity basis set on which future design of MK-801 agonists and antagonists can be based is now available.
There is still a lot of research devoted to this compound(SMILES：NC1CCNCC1.[H]Cl.[H]Cl)Computed Properties of C5H14Cl2N2, and with the development of science, more effects of this compound(35621-01-3) can be discovered.
Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia