The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Biological radiation protection. LIX. The meaning of radiation-caused changes in the content of metabolites to the survival rate of mice》. Authors are Melching, Hans Joachim; Abe, Mitsuyuki; Streffer, Christian.The article about the compound:5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloridecas:148-51-6,SMILESS:OC1=C(C)C(CO)=CN=C1C.[H]Cl).Quality Control of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride. Through the article, more information about this compound (cas:148-51-6) is conveyed.
After radiation, changes occur in albumin metabolism, especially in the case of tryptophan and cysteine. The changes reflect a curbing of the activity of amino acid decarboxylase with pyridoxal 5-phosphate as coenzyme. The following compounds increased the mortality rate when given with an x-ray dose of 505 r. (L.D.16/30): 4-deoxypyridoxine-HCl, isonicotinic acid hydrazide,DL-tryptophan, DL-kynurenine, and L-kynurenine. Taurine, given with 590 r. (L.D.64/30), increased the survival rate.
There is still a lot of research devoted to this compound(SMILES：OC1=C(C)C(CO)=CN=C1C.[H]Cl)Quality Control of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride, and with the development of science, more effects of this compound(148-51-6) can be discovered.
Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia