Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 302964-08-5, name is 2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide. A new synthetic method of this compound is introduced below., 302964-08-5
j00388j A solution of 1 -(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)piperazine (300mg, 0.926 mmol) in DMF (7.5 mL) was charged with potassium carbonate (383 mg, 2.77 mmol) and 2-((6-chloro-2-methylpyrimidin-4-yl)amino-N- (2-chloro-6-methylphenyl)thiazole- 5-carboxamide (255 mg, 0.648 mmol). The reaction mixture was heated to 90C in a sealed tube for 14 h. The reaction mixture was diluted with water (10 mL) and extracted with ethylacetate (3 X 30 mL). The combined organic layers were dried over anhydrous Na2504, filtered and concentrated in vacuo resulting in a crude compound which was purified by chromatography on silica gel, eluting with 3-5% methanol in DCMto give 100 mg, 15% yield of the title compound as light yellow solid. ?H NMR (400 MHz, DMSO-d6): oe = 9.89 (d, J= 15.3 Hz, 1H), 8.21 (d, J= 7.7 Hz, 1H), 7.40 (dd, J= 7.5, 2.0 Hz, 1H), 7.21 -7.32 (m, 2H), 6.02 (s, 1H), 5.76 (s, 1H), 3.74- 3.83 (m, 4H), 3.28 – 3.54 (m, 18H), 2.44 (d, J= 4.5 Hz, 3H), 2.23(d, J= 4.7 Hz, 3H), 1.23 (t, J= 4.9 Hz, 2H); MS (ESj: m/z = 645.5, 647.5, 648.5 [M+H]LCMS: tR = 2.88 mm.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,302964-08-5, 2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide, and friends who are interested can also refer to it.
Reference:
Patent; COFERON, INC.; FOREMAN, Kenneth, W.; JIN, Meizhong; WANNER, Jutta; WERNER, Douglas, S.; WO2015/106292; (2015); A1;,
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