36315-01-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 36315-01-2 as follows.
24.5g carbamate, 11.8g 4,6-dimethoxy-2-pyrimidinamine, 200mL tolueneMix and put into the reaction vessel and heat to reflux. After about 0.5h, start to collect the mixed solution of toluene and ethanol.Fresh toluene was added at the same speed, and the reaction was completed after refluxing for 5h. Stop adding toluene, distill off some toluene, cool to room temperature, and filter.After drying, 24.6 g of nicosulfuron was obtained, the mass fraction was 95.0%, and the yield was 75.6%.
The chemical industry reduces the impact on the environment during synthesis 36315-01-2, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Heilongjiang Suihua Farming Chenhuan Biological Preparation Co., Ltd.; Du Chuanyu; Zhao Mingxin; Jiang Yushan; Zhou Dewei; Wang Weisheng; (7 pag.)CN111269214; (2020); A;,
Pyrimidine | C4H4N2 – PubChem,
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