Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 125401-75-4, name is 2,6-Bis((4,6-dimethoxypyrimidin-2-yl)oxy)benzoic acid. This compound has unique chemical properties. The synthetic route is as follows. 125401-75-4
EXAMPLE 1 Preparation of 1-ethoxycarbonyloxyethyl 2,6-bis[(4,6-dimethoxypyrimidin -2-yl)oxy]benzoate (Compound No. 5) 1.7 g (4.0 mmol) of 2,6-bis[(4,6-dimethoxypyrimidin-2-yl) oxy]benzoic acid and 0.2 g of 60% sodium hydride were dissolved in N,N-dimethylformamide. After the generation of hydrogen ceased, 0.68 g (4.4 mmol) of 1-chloroethylethylcarbonate was added to the solution and the resultant mixture was reacted at 100 C. for 1 hour. After completing the reaction, the reaction mixture was added to ice water and was extracted with ethyl acetate. The ethyl acetate layer was dried with anhydrous sodium sulfate, and the ethyl acetate was distilled off. The residue was purified by silica gel column chromatography, and ethanol/hexane were added thereto to precipitate a solid, which was then filtered out to obtain 1.4 g of a white crystal having a melting point of from 97 to 100 C.
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Reference:
Patent; Kumiai Chemical Industry Co. Ltd.; Ihara Chemical Industry Co., Ltd.; US5154750; (1992); A;,
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