So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Horton, R. W.; Meldrum, B. S. researched the compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride( cas:148-51-6 ).Reference of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride.They published the article 《Preconvulsive changes in brain glucose metabolism following drugs inhibiting glutamate decarboxylase》 about this compound( cas:148-51-6 ) in Journal of Neurochemistry. Keywords: convulsant brain glucose glycogen; allylglycine brain glucose glycogen; deoxypyridoxine brain glucose glycogen; methionine sulfoximine brain glucose; isoniazid brain glucose glycogen; temperature brain glucose convulsant. We’ll tell you more about this compound (cas:148-51-6).
DL-C-allylglycine (I) [7685-44-1], 4-deoxypyridoxine-HCl (II) [148-51-6], and DL-methionine-D-sulfoximine (III) (180, 250, and 300 mg/kg resp., i.p.) each induced preconvulsive increases in the brain glucose [50-99-7] concentration of mice at room temperature; II and III also increased brain glycogen [9005-79-2] concentrations in room-temperature mice, but only II did so in mice maintained at 33-4°. Only with I was the increase in brain glucose concentration associated with an increase in blood glucose concentration I, II, III, or isoniazid [54-85-3] (150 mg/kg) reduced rectal temperature in mice at room temperature but not those at 33-4°. Isoniazid reduced brain glucose and glycogen concentrations in mice at 33-4°, but did not affect mice at room temperature The relation between the effects of these drugs on brain carbohydrates and amino acid metabolism is discussed.
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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia