The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride( cas:148-51-6 ) is researched.HPLC of Formula: 148-51-6.Koerner, Wilhelm F.; Nowak, Herbert published the article 《Quantitative determination of the biological antivitamin B6 effect of pyridoxol antagonists》 about this compound( cas:148-51-6 ) in Internationale Zeitschrift fuer Vitaminforschung. Keywords: PYRIDOXOL DEOXY VITAMIN B6; DEOXYPYRIDOXOL VITAMIN B6; ANTIVITAMIN B6 PYRIDOXOLS; VITAMIN B6 PYRIDOXOLS. Let’s learn more about this compound (cas:148-51-6).
Rats were fed a vitamin B6-free diet for 20 days; however, during the last 10 days the diets were supplemented with 30 γ pyridoxol-HCl. During the next 5 days, the animals were loaded with daily oral doses of 200 mg. L-tryptophan/kg., and during days 26-30 of the experiment 4′-deoxypyridoxol-HCl (0.1-100 mg./kg.) was given i.p. 4′-Deoxypyridoxol-HCl had an antivitamin B6 activity (measured by xanthinuric acid excretion) beginning at the 0.3 mg./kg. dose. The antivitamin B6 activity of pyramin-HCl (10-100 mg./kg.) was 60% that of 4′-deoxypyridoxol-HCl.
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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia