So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Birkinshaw, Timothy N.; Teague, Simon J.; Beech, Claire; Bonnert, Roger V.; Hill, Stephen; Patel, Anil; Reakes, Sara; Sanganee, Hitesh; Dougall, Iain G.; Phillips, Tim T.; Salter, Sylvia; Schmidt, Jerzy; Arrowsmith, Elizabeth C.; Carrillo, Juan J.; Bell, Fiona M.; Paine, Stuart W.; Weaver, Richard researched the compound: 4-Chloro-8-methylquinoline( cas:18436-73-2 ).Application of 18436-73-2.They published the article 《Discovery of potent CRTh2 (DP2) receptor antagonists》 about this compound( cas:18436-73-2 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: CRTh2 receptor antagonist discovery preparation antiinflammatory structure. We’ll tell you more about this compound (cas:18436-73-2).
Starting with the weak agonist indomethacin, a series of potent, selective CRTh2(DP2) antagonists have been discovered as potential treatments for asthma, allergic rhinitis and other inflammatory diseases.
As far as I know, this compound(18436-73-2)Application of 18436-73-2 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia