932-52-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 932-52-5, name is 5-Aminopyrimidine-2,4(1H,3H)-dione. This compound has unique chemical properties. The synthetic route is as follows.
Intermediate 1 : Dimethyl (2E)-2-r(2,4-dioxo-1 ,2,3,4-tetrahvdropyrimidin-5-yl)amino1but- 2-enedioate; To a suspension of 5-aminouracil (275 g, 2.16 mol) in dry methanol (5.5 L) was added dropwise dimethyl acetylene dicarboxylate (344 g, 2.42 mol) at room temperature. After the end of the addition, the mixture was stirred at room temperature for 24 hours. The precipitate was filtered off, washed with MeOH (500 mL) and dried under vacuum to afford the title compound (430 g, 74%) as a yellow solid.LC/MS (Method A) : RT 0.87 min (purity : 96%). MS (ES-) : 267.6. 1H NMR (400 MHz, DMSO-ds) delta 11.33 (br s, 1 H), 10.82 (br s, 1 H), 9.07 (s, 1 H), 7.42 (s, 1 H),5.21 (s, 1 H), 3.65 (s, 3H), 3.63 (s, 3H).
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Reference:
Patent; MERCK SERONO S.A.; MONTAGNE, Cyril; BOMBRUN, Agnes; DESFORGES, Gwenaelle; QUATTROPANI, Anna; GAILLARD, Pascale; WO2010/91996; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
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