The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Piperidin-4-amine dihydrochloride( cas:35621-01-3 ) is researched.Name: Piperidin-4-amine dihydrochloride.Shirahata, Akira; Morohohi, Toru; Fukai, Masayo; Akatsu, Sakae; Samejima, Keijiro published the article 《Putrescine or spermidine binding site of aminopropyltransferases and competitive inhibitors》 about this compound( cas:35621-01-3 ) in Biochemical Pharmacology. Keywords: synthase spermine spermidine inhibitor active site; aminopropyltransferase putrescine spermidine site inhibitor. Let’s learn more about this compound (cas:35621-01-3).
A model of the active site of aminopropyltransferases was proposed based on the study of a number of monoamino and diamino compounds as potential inhibitors and substrates, resp., of spermidine synthase purified from pig liver. The active site seems to have a relatively large hydrophobic cavity adjacent to a neg. charged site, to which a protonated amino group of putrescine binds, with another amino group of putrescine being situated in the hydrophobic cavity as a free form to be aminopropylated by decarboxylated S-adenosylmethionine. On the basis of the above-mentioned model, another modified one was proposed for spermine synthase, and several compounds designed according to the modified model were found to potently inhibit spermine synthase, purified from rat brain, in competition with spermidine. The newly developed inhibitors were about two orders of magnitude more potent in vitro than a known inhibitor of spermine synthase, dimethyl(5′-adenosyl)sulfonium perchlorate.
As far as I know, this compound(35621-01-3)Name: Piperidin-4-amine dihydrochloride can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia