147118-40-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 147118-40-9 as follows.
Chromatographic column:LiChrospher 100 DIOL 10 mum 250 x 20mm Mobile phase A:diisopropyl ether (DIPE) Mobile phase B:1,5percent isopropanol, 98,5percent DIPE Flow rate:60 ml/min Detection:UV, 345 nm Injection volume:60 ml 1,5 g of the crude sample (assay 70percent) is dissolved in 60 ml of diisopropylether. The obtained solution is loaded on a chromatographic column, previously conditioned with mobile phase A. After the sample load the chromatographic column is eluted with mobile phase B. A central portion (ca 100 ml) of main peak is collected. The obtained fraction is pure MER, with ca 99,8 percent chromatographic purity, and ca 6-7percent of enantiomer, as shown on Fig.3
The chemical industry reduces the impact on the environment during synthesis 147118-40-9, I believe this compound will play a more active role in future production and life.
Reference:
Patent; LEK Pharmaceuticals d.d.; EP2022784; (2009); A1;,
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