As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 372118-67-7, name is Pyrimidin-2-ylmethanamine hydrochloride, molecular formula is C5H8ClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 372118-67-7
A mixture of methyl amino pyrimidine (250 mg, 1 eq, 1.718 mmol), FMOC-NCS (531 mg, 1.1 eq, 1.9 mmol) and diisopropyl ethyl amine (0.3 ml, 1 eq, 1,718 mmol) was stirred in 1,4-dioxane (10 ml) at 25 C overnight under argon atmosphere. A solid separated out from mixture was filtered and washed with water and ethyl acetate, and dried under high vaccuum. Yield 658 mg, 98%. Solid obtained from the reaction (658 mg, 1 eq, 1.2 mmol) was stirred in piperidine (3 ml) and dichloromethane (15 ml) at 25 C overnight. A solid percipitate was collected by filtration and washed with dichloromethane and water to give a white solid. Yield 289 mg, 98%.LCMS, 169 (MH+).
The chemical industry reduces the impact on the environment during synthesis 372118-67-7, I believe this compound will play a more active role in future production and life.
Reference:
Patent; BARUCH S. BLUMBERG INSTITUTE; DU, Yanming; LU, Huagang; ROGOWSKY, John; KINNEY, William, A.; CUCONATI, Andrea; (76 pag.)WO2018/13508; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia