Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3740-92-9, name is 4,6-Dichloro-2-phenylpyrimidine. A new synthetic method of this compound is introduced below., 3740-92-9
In a 250-mL three-neck flask, nitrogen was introduced and 0.01 mol of intermediate A20, 150 ml of DMF, 0.012 mol of intermediate B1, and 0.0001 mol of palladium acetate were added.Stir, then add 0.01mol K3PO4 aqueous solution, heated to 150 ¡ãC,The reaction was refluxed for 24 hours. Samples were taken and the reaction was complete.Cool naturally, extract with 200ml dichloromethane, layerThe extract was dried over anhydrous sodium sulfate, filtered, and the filtrate was evaporated.Purification by silica gel column to give intermediate C1, HPLC purity 99.2percentThe yield was 85.1percent.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,3740-92-9, 4,6-Dichloro-2-phenylpyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Wang Fang; Zhang Zhaochao; Li Chong; Zhang Xiaoqing; (53 pag.)CN107602538; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia